interleukin 5 การใช้

• The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor.
• Through binding to the interleukin-5 receptor, interleukin 5 stimulates B cell growth and increases immunoglobulin secretion.
• The Th2 response is characterized by the release of Interleukin 5, which induces eosinophils in the clearance of parasites.
• Th2 immune responses result in the release of cytokines associated with inflammation reduction such as interleukin 4, interleukin 5 and interleukin 10.
• However, their production is stimulated in human eosinophils by physiological agonists such as prostaglandin D2, leukotriene C4, and interleukin 5.
• The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 ( IL3 ), colony stimulating factor 2 ( CSF2 / GM-CSF ), and interleukin 5 ( IL5 ).
• Human and animal studies have provided evidence of decreased Th1 and Th17 immune responses with a shift to Th2 cytokine production resulting in significantly decreased levels of interleukin 12 and IFNy with simultaneous increases in the regulatory T cells, interleukin 4, interleukin 5 and interleukin 10 of test subjects.
• It dilates airways ( bronchodilation ) contracted by the allergic mediator, histamine; inhibits Immunoglobulin E-activated mast cells from releasing histamine and leukotrienes ( viz ., LTC4, LTD4, and LTE4 ), all of which have bronchoconstricting and otherwise pro-allergic actions; inhibits pro-allergic eosinophil apoptosis, chemotaxis, and release of pro-allergic granule contents; and reduces release of the pro-allergic cytokines Interleukin 5, Interleukin 4, and interleukin 13 from human blood mononuclear cells.